Day 2 :
- Ophthalmic Genetics and Gene Therapy | Optical Imaging and Sensing | Optical Technologies and Laser Science in Ophthalmology | Ophthalmology Surgery
Location: Vancouver, Canada
Session Introduction
Idiberto Jose Zotarelli-Filho
Ophthalmology and Eye Plastic, Brazil
Title: Cellular therapy for intravitreal use in ischemic retinopathy and macular degeneration: A systematic review
Biography:
Idiberto José Zotarelli Filho worked at Clinical Unioftal, Brazil, specializing in a wide range of ophthalmic and aesthetic services, offering routine examinations, diagnosis, and treatment of various eye diseases, as well as conducting eye surgeries, eye plastics procedures, and providing advanced aesthetic treatments.
Abstract:
Introduction: In the scenario of eye diseases, diabetic retinopathy and retinal vein occlusion are the two most common ischemic retinopathies in the world. Ischemia is caused by retinal vascular diseases due to decreased blood perfusion and the appearance of areas of retinal non- perfusion. Also, age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in people over 65 years of age in industrialized countries. By 2020 around 200 million people will be affected by AMD worldwide.
Objective: The present systematic review study aimed to highlight the main clinical findings of the treatment of ischemic retinopathy and age-related macular degeneration through cell therapy with bone marrow stem cells.
Methods: The rules of the Systematic Review-PRISMA Platform were followed. The search was carried out from March 2022 to June 2022 in Scopus, PubMed, Science Direct, Scielo and Google Scholar databases. The quality of the studies was based on the GRADE instrument. The risk of bias was analyzed according to the Cochrane instrument.
Results and Conclusions: It was found 235 articles involving retinitis pigmentosa, macular degeneration, and bone marrow stem cell therapy. A total of 51 were fully evaluated and 28 studies were included and developed in a systematic review in the results field. The symmetrical Funnel Plot does not suggest a risk of bias between the small sample size studies. It was concluded that intravitreal injection of bone marrow-derived stem cells in a patient with retinal vascular occlusion sequelae demonstrated that the procedure is feasible and safe to be performed in humans as there were no signs of infection, inflammation or development of intraocular tumor formation. Also, neurotrophic effects correlate with vasculature preservation, suggesting that bone marrow-derived stem cells can be used in the treatment of diseases such as retinal degenerations and vasculopathy that currently lack effective treatment. The authors concluded that stem cells can protect retinal cells from degeneration and also suggested that they were able to replace some types of lost retinal neurons.
Mostafa Bondok
University of British Columbia, Canada
Title: Addressing unmatched ophthalmology applicants in canadian residency programs: Exploring viable solutions
Biography:
Mostafa Bondok has a background in Medical Education, Health Equity, Accessibility Technology, and Methodological studies. He is a medical student at the University of British Columbia.
Abstract:
Statement of the Problem: Applicants to ophthalmology have experienced disproportionately higher rates of going unmatched during the CaRMS process compared to other specialties. Our research aims to examine this phenomenon by identifying trends and comparing match data to other specialties.
Methodology & Theoretical Orientation: Using a retrospective, cross-sectional design, Qualitative trends in CaRMS outcomes of ophthalmology applicants were compared to other specialties from 2013-2022.
Findings: Data was obtained from 608 ophthalmology, 5,153 surgery, and 3,092 top five (most competitive) specialty first choice applicants from 2013-2022. Ophthalmology applicants were more likely to go unmatched (18.9% [120/608]) than applicants to the top five (11.9% [371/3,092]) and surgical (13.5% [702/5,153]) specialties (p<0.001) and were twice as likely to rank no alternate disciplines (31.8%; p<0.001) over the study period. In the first iteration, when alternate disciplines were ranked, match rate to alternate disciplines was highest for ophthalmology applicants (0.41; p<0.001). The majority (57.8%) of unmatched ophthalmology applicants do not participate in the second iteration.
Statement of the Problem: Applicants to ophthalmology have experienced disproportionately higher rates of going unmatched during the CaRMS process compared to other specialties. Our research aims to examine this phenomenon by identifying trends and comparing match data to other specialties.
Methodology & Theoretical Orientation: Using a retrospective, cross-sectional design, Qualitative trends in CaRMS outcomes of ophthalmology applicants were compared to other specialties from 2013-2022.
Findings: Data was obtained from 608 ophthalmology, 5,153 surgery, and 3,092 top five (most competitive) specialty first choice applicants from 2013-2022. Ophthalmology applicants were more likely to go unmatched (18.9% [120/608]) than applicants to the top five (11.9% [371/3,092]) and surgical (13.5% [702/5,153]) specialties (p<0.001) and were twice as likely to rank no alternate disciplines (31.8%; p<0.001) over the study period. In the first iteration, when alternate disciplines were ranked, match rate to alternate disciplines was highest for ophthalmology applicants (0.41; p<0.001). The majority (57.8%) of unmatched ophthalmology applicants do not participate in the second iteration.
Asaad A Ghanem
Mansoura University, Egypt
Title: Correlation between corneal elevation topography and perimetric changes in patients with primary open angle glaucoma
Biography:
Asaad A Ghanem has completed his MD at the age of 35 years from Mansoura University, Egypt. He is the head of Glaucoma department of Mansoura University, Egypt. He has over 70 publications that have been cited over 453 times, and his publication h-index is 14. He has been serving as an editorial board member of several reputed journals.
Abstract:
Aim: The aim of this study is to assess Scheimpflug topographic elevation maps in patients with POAG and correlate the results with their perimetric changes.
Methods: This was an analytical observational cross-sectional study. The study included 130 eyes of 70 subjects which were divided into 78 eyes of 44 patients diagnosed with POAG and 52 eyes of 26 control subjects. Measurement of IOP, visual field examination in patients with POAG using Humphrey Field Analyzer (2003 Carl Zeiss Meditec), Germany were done. Subjects were scanned using TMS-5 topographer (Topographic Modeling System, version 5. Tomey Corp. Nagoya, Japan) to measure central corneal thickness, mean anterior keratometry, maximum anterior and posterior topographic elevation maps in the central 3, 5, and 7 mm.
Results: 78 patients with POAG classified according to visual field deterioration using Hodapp-Anderson-Parrish grading scale into mild glaucoma 33 eyes, moderate glaucoma 19 eyes, severe glaucoma 26 eyes and 52 eyes control were included in the study. The mean age of the patients with POAG was 57.82 ± 7.78 years; 22 eyes (50%) were male and 22 eyes (50%) were female. The average age of control subjects was 56.62 ± 8.48 years; 12 eyes (46.2%) were male and 14 eyes (53.8%) were female, average CCT was 530.3 ± 23.58 µm, average mean anterior keratometry (MAK) was 42.97 ± 1.42 D, average maximum anterior elevation (MAE) in 3,5 and 7mm zone was 5.31 ± 2.28, 12.10 ± 6.94 and 44.04 ± 21.99 µm respectively and average maximum posterior elevation (MPE) in 3,5 and 7mm zone was 8.46 ± 2.10, 19.90 ± 9.39 and 62.72 ± 28.82 µm respectively in patients with POAG, whereas average CCT was 543.0 ± 31.02µm, average MAK was 43.11 ± 1.73 D, average MAE in 3,5 and 7mm zone was 4.52 ± 1.97, 5.90 ± 2.71 and 27.19 ± 8.55 µm respectively.
Conclusion: Evaluation of corneal elevation topography by scheimpflug imaging showed forward shifting of the anterior and posterior corneal surfaces in POAG.
Marrie A.
Cairo University, Egypt
Title: The safety and efficacy of black tea extract in the treatment of acute bacterial conjunctivitis: A rabbit model
Biography:
Marrie A is an assistant professor in Cairo University, Egypt specialized in cornea and refractive.
Abstract:
Purpose: To determine the safety and efficacy of black tea extract in the treatment of bacterial conjunctivitis in a rabbit model and compare it with that of gatifloxacin drops.
Methods: Black tea extract was tested in vitro on bacterial cultures of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Forty-two rabbit eyes were cultured with either MRSA (n.21) or P. aeruginosa (n.21) and further divided into a control group (n.5), a tea group (n.8) treated with black tea extract and a gatifloxacin group (n.8) treated with 0.3% gatifloxacin eye drops. Conjunctival swabs were collected on the third and fifth days.
Results: The tea extract successfully inhibited the growth of both organisms at a concentration of 400 mg/mL. Rabbits in the treatment groups showed a reduction in the clinical index on day 2 (P, 0.01), unlike the control group (P.0.1), for both organisms. Resolution of conjunctivitis was achieved on days 4 and 5 in the tea and gatifloxacin groups, respectively. On days 3 and 5, while the control group still showed considerable bacterial growth, the tea and gatifloxacin groups showed its inhibition.
Conclusion: Tea extract has antimicrobial effects similar to those of gatifloxacin in a rabbit model of conjunctivitis.
Key Words: Tea extract, Conjunctivitis, MRSA, Pseudomonas aeruginosa